To investigate the pathogenicity and virological properties of TJ-89-2 strain of canine parvovirus(CPV-2) that was isolated from the diseased puppies in Korea, seven puppies were inoculated intraorally with the isolate at the HA titer of 8,192. All of the puppies showed the signs of anorexia, vomiting, diarrhea and died at the 5th to l0th days post inoculation(pi).
All of the fecal samples from the puppies revealed significantly high HA titers afterward the 5th days pi. Body temperature and the number of total leucocytes were slightly increased at the early stage of infection, but extremely decreased at the stage of collapse. HI titers of the sera began to increase at the 3rd to 4th days pi, reaching 512 to 1,024 at the 4th to 5th days pi.
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